Rigore scientifico: la forza e l’unicità dei dati chimico-fisici e farmacologici

Gli effetti degli integratori-nutraceutici possono essere valutati a livello sintomatico, ad esempio sul dolore e sull’infiammazione, mediante l’impiego di scale analogiche o tramite questionari specifici, o ancora mediante microanalisi sui marker infiammatori correlati, oppure tramite il monitoraggio dei livelli ematici (es. della vitamina D o di altre vitamine) pre- e post-trattamento in rapporto ai benefici attesi.

PUBBLICAZIONI INDICIZZATE PUBMED

  1. Curcuma (3908 pubblicazioni ) : Curcumin is known recently to have antioxidant, anti-inflammatory, anticancer effects and, thanks to these effects, to have an important role in prevention and treatment of various illnesses ranging notably from cancer to autoimmune, neurological, cardiovascular diseases, and diabetic
  2. Centella (Centella asiatica) (821 pubblicazioni)
  3. Ananas gambo estratto secco (721 pubblicazioni)
  4. Cardo mariano (1048 pubblicazioni) : Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
  5. Ippocastano (766 pubblicazioni)
  6. Monacolina K del Riso Rosso Fermentato (440 pubblicazioni)

Efficacy of red yeast rice extract on myocardial infarction patients with borderline hypercholesterolemia: A meta-analysis of randomized controlled trials. Sungthong B1, Yoothaekool C2, Promphamorn S2, Phimarn . Sci Rep. 2020 Feb 17;10(1):2769

Abstract

Red yeast rice (RYR) extract is widely used for improving cardiovascular outcomes and lipid profiles. However, RYR efficacy on cardiovascular outcomes in myocardial infarction (MI) patients remains unclear. This meta-analysis assessed efficacy of RYR extract in MI patients with borderline hypercholesterolemia. PubMed, CENTRAL, CINAHL, Scopus, Web of Science, and Clinicaltrials.gov were systematically searched from inception through May 2019 for relevant publications. Seven studies with 10,699 MI patients diagnosed with borderline hypercholesterolemia were included. Follow-up periods ranged from 4 weeks – 4.5 years and the studies were overall of high quality with low risk of bias. RYR extract (1,200 mg/day) reduced nonfatal MI (risk ratio (RR) = 0.42, 95% CI 0.34 to 0.52), revascularization (RR = 0.58, 95% CI 0.48 to 0.71), and sudden death (RR = 0.71, 95% CI 0.53 to 0.94). RYR extract also lowered LDL (weighted mean difference (WMD) = -20.70 mg/dL, 95% CI -24.51 to -16.90), TC (WMD = -26.61 mg/dL, 95% CI -31.65 to -21.58), TG (WMD = - 24.69 mg/dL, 95% CI -34.36 to -15.03), and increased HDL levels (WMD = 2.71 mg/dL, 95% CI 1.24 to 4.17). This meta-analysis indicated that RYR extract in MI patients with borderline hypercholesterolemia is associated with improved cardiovascular outcomes and lipid profiles.

  • Berberis Aristata estratto secco (90 pubblicazioni)

The Effects of a Fixed Combination of Berberis aristata and Silybum marianum on Dyslipidaemia – A Meta-analysis and Systematic Review.

Tóth B1,2, Németh D3, Soós A3, Hegyi P3, Pham-Dobor G4, Varga O5, Varga V1,2, Kiss T1,2, Sarlós P4, Erőss B3, Csupor D1,2. Planta Med. 2020 Jan;86(2):132-143

  1. Coenzima Q10 (4522 pubblicazioni)
  2. Vitamina E (43494 pubblicazioni)

Complement Ther Clin Pract. 2020 May; 39:101142.

Comparative efficacy of vitamin supplements on prevention of major cardiovascular disease: Systematic review with network meta-analysis.

Han J1, Zhao C1, Cai J2, Liang Y3.

Abstract

BACKGROUND: Vitamins are commonly used in the prevention of major cardiovascular disease. However, the efficacy and optimum choice remain controversial.

OBJECTIVE: To compare and rank the relative efficacy among all available vitamin preparations for cardiovascular disease through a network meta-analysis.

METHODS: Eligible studies were identified by searching PubMed, Embase, Medline, Cochrane library and Web of Science for randomized controlled trials. A random effects model was applied within a frequentist framework.

RESULTS: Forty-two articles (45 comparisons, 384,248 participants), including nine vitamin interventions, were identified. Vitamin D had the highest probability of being ranked best in effectiveness (0.84 [0.72, 0.98]) on prevention of cardiovascular events. With regard to reducing death of cardiovascular disease rate, vitamin E was considered better efficacy.

CONCLUSIONS: Vitamin B, D and E could reduce the incidence of cardiovascular events to varying degrees. At the same time, the combination of vitamins can not show improvement on the efficacy.

  1. Vitamina B6 (20156 pubblicazioni)
  2. Vitamina B12 (32229 pubblicazioni)
  3. Acido folico (40507 pubblicazioni)
  4. Spaccapietra (Phyllanthus niruri) (185 pubblicazioni)
  5. Tè verde Camellia sinensis Epigallocatechin-3-gallate (EGCG) (4928 pubblicazioni)

Epigallocatechin-3-gallate (EGCG) is the most abundant catechin contained in green tea (Camellia sinensis) and has been associated with anti-obesity and anti-cancer effects, but the exact molecular mechanisms remain elusive. In this context, this study was designed to improve the understanding of the EGCG anti-obesity and anti-cancer action.

  1. Cranberry (1665 pubblicazioni)

Cranberry Consumption Against Urinary Tract Infections: Clinical State of- the-Art and Future Perspectives.

Mantzorou M1, Giaginis C1. Curr Pharm Biotechnol. 2018; 19 (13):1049-1063.

Abstract

INTRODUCTION: Urinary tract infections (UTIs) represent a common and costly public health issue. The bacterium Escherichia coli is mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have extensively been studied in order to understand the molecular mechanisms of action of its bioactive components and their clinical benefits against UTIs. In this respect, the present review aims to critically analyze the current clinical studies that have evaluated the efficacy of supplementing cranberry products against UTIs in different subpopulations.

METHODS: PubMed database was comprehensively searched, using relative keywords in order to identify clinical trials exploring the efficacy of cranberry supplementation against UTIs.

RESULTS: Current clinical evidence clearly indicates a possible benefit overall from the use of cranberries against UTIs. Cranberry consumption may prevent bacterial adherence to uroepithelial cells, reducing UTI related symptoms. Cranberry consumption could also decrease UTI related symptoms by suppressing inflammatory cascades as an immunologic response to bacterial invasion. The existing clinical trials have supported substantial evidence that the beneficial effects of cranberry against UTIs seem to be prophylactic by preventing infections recurrence; however, they exert low effectiveness in populations at increased risk for contracting UTIs. Moreover, a lack of cost-effectiveness for cranberry supplementation has been  highlighted.

CONCLUSIONS: Additional well-designed, double-blind, placebo-controlled clinical trials that use standardized cranberry products for long study periods are strongly recommended in order to determine the efficiency of cranberry on the prevention of UTIs in susceptible populations. At present, cranberry supplementation can safely be suggested as complementary therapy in women with recurrent UTIs.

  1. Orthosiphon (179 pubblicazioni)

Orthosiphon stamineus: traditional uses, phytochemistry, pharmacology, and toxicology. Ameer OZ1, Salman IM, Asmawi MZ, Ibraheem ZO, Yam MF. J Med Food. 2012 Aug;15 (8):678-90

  1. Betulla (3056 pubblicazioni)
  2. Verga d’oro (Solidago canadensis) (golden rod) (606 pubblicazioni).